Worldkiller Prophecy (Earth-Prime)

"You really thought you could stop me, Supergirl? You can't even protect this one pathetic human."

- Reign to Supergirl

Worldkiller Prophecy was the Children of Juru's prophecy involving the Kryptonian Worldkillers.

Conflict
In 2017, the Children of Juru began their Worldkiller Prophecy, with Samantha Arias' inner "Reign" personality starting to surface. As Reign, Arias became an enemy of Supergirl and was near the completion of the prophecy. However, with the effort of the Super Friends and the Legion of Superheroes, Reign was defeated after being separated from Arias, making her free of her dangerous alter once and for all.